Recent OAI Publications

CONCLUSION: A greater 2-year change in total thigh muscle CSA, corresponding to greater gain or less loss, was associated with a lower incidence of subsequent THA. Conversely, lower change values or greater CSA loss were associated with higher subsequent THA incidence. Findings for individual muscle regions and alternative processing methods did not remain significant after false discovery rate correction and should be interpreted as exploratory. Longitudinal total thigh muscle CSA may warrant...

CONCLUSIONS: KOA-Diff synthesizes future radiographs reflecting accurate structural progression, providing an interpretable tool for KOA prediction.

CONCLUSION: Baseline MOAKS features provided prognostic information beyond radiographic or clinical-radiographic severity for fixed 48-month medial JSN progression. In this selected MOAKS-scored cohort, adding a baseline-radiograph ResNet50 encoder did not improve discrimination over the structured models. The finite number of test events, selected MOAKS availability, calibration requirements, and lack of external validation preclude claims of clinical readiness.

CONCLUSIONS: CAM use, particularly chiropractic therapy, was associated with a small but statistically significant reduction in knee pain in patients with KOA. Given the modest effect size and observational design, these findings warrant further prospective evaluation of chiropractic care as a non-pharmacological option.

CONCLUSION: We report the development of an accurate and rapid offset measurement model using deep learning that can be applied before and after THA. Future work will involve external model validation.

CONCLUSIONS: Thigh muscle gain was associated with less progression in ligamentous damage and bone marrow edema-like lesions and pain, whereas muscle loss was associated with greater tendon progression and decline in physical performance.

INTRODUCTION: The International Workshop on Osteoarthritis Imaging (IWOAI) was founded in 2007 to create a focused scientific forum dedicated to imaging (biomarkers) in osteoarthritis. In contrast to large international congresses, the workshop was conceived as a small and interactive meeting encouraging open discussion and interdisciplinary exchange among researchers from academia and industry.

CONCLUSION: Two distinct phenotypes/trajectories were consistently identified across all four knee symptom measurements in a multi-trajectory model. Modifiable factors such BMLs, BMI, widespread pain and depression may serve as indicators of higher risk of rapid knee symptom progression.

CONCLUSION: AI-based cartilage segmentation performed at least as well as manual expert analysis in separating knees with subsequent knee replacement from controls. This was consistent across MRI acquisitions with different orientations and contrasts. The findings support automated MRI-based cartilage morphometry as a scalable imaging biomarker associated with a clinically meaningful outcome.

CONCLUSIONS: Worse symptomatic, radiographic, and structural knee status is associated with contralateral radiographic OA progression, suggesting contralateral knee condition should be considered in OA evaluation.

CONCLUSION: While specific protein-rich food groups are cross-sectionally linked to baseline synovial inflammation volume, dietary factors are not robustly associated with the short-term progression of effusion-synovitis in knees at risk of KOA. These findings suggest that dietary intake may correlate with the inflammatory "set-point" of the joint but has limited influence on active 12-month inflammatory fluctuations, highlighting the complexity of inflammatory mechanisms in early KOA.

CONCLUSION: Quantitative MRI radiomics of the IPFP provide a promising tool for predicting KOA pain progression.

CONCLUSIONS: Larger IPFP(Vol) was associated with greater patellofemoral cartilage thickness and less severe osteoarthritis features in the patellofemoral and lateral tibiofemoral joint. These findings highlight the subregion-specific relationship between IPFP volume, knee cartilage thickness and imaging features of osteoarthritis.

By the time the orthopaedic surgeon sees a patient with symptomatic knee osteoarthritis, the disease has already progressed to an advanced stage. As a result, studying the full natural history of the knee is especially difficult. A few large longitudinal cohorts, the Osteoarthritis Initiative and Multicenter Osteoarthritis Study in particular, provide the bulk of the data for most extant studies. In this review, we report on the current state of knowledge regarding the study of the natural...

Background Vascular factors have been associated with osteoarthritis (OA), but the association between popliteal artery wall morphology and symptomatic and radiographic knee OA outcomes over time remains unclear. Purpose To evaluate the associations between MRI-derived measures of popliteal artery wall morphology (localized wall thickening and global wall burden) and symptomatic and radiographic knee OA outcomes. Materials and Methods In this secondary analysis of the Osteoarthritis Initiative...